Astros Today’s Lineup vs. Guardians — April 21, 2026

April 21, 2026

The Houston Astros have released their lineup for today’s game against the Cleveland Guardians at Progressive Field.

Game Details

Date: April 21, 2026
First pitch: 5:10 p.m. CT
Location: Progressive Field, Cleveland, OH

How to Tune In

TV: Space City Home Network (SCHN)
Streaming: SCHN+ app (with provider login)
Radio: KBME 790 AM / 94.5 FM HD-2

Astros Starting Lineup

  1. Carlos Correa (R) SS
  2. Yordan Alvarez (L) DH
  3. Jose Altuve (R) 2B
  4. Christian Walker (R) 1B
  5. Isaac Paredes (R) 3B
  6. Cam Smith (R) RF
  7. Yainer Diaz (R) C
  8. Brice Matthews (R) CF
  9. Dustin Harris (L) LF

SP: Ryan Weiss (RHP)

Guardians Starting Lineup

  1. Steven Kwan (L) CF
  2. Chase DeLauter (L) DH
  3. José Ramírez (S) 3B
  4. Kyle Manzardo (L) 1B
  5. George Valera (L) RF
  6. Daniel Schneemann (L) 2B
  7. Angel Martínez (S) LF
  8. Austin Hedges (R) C
  9. Brayan Rocchio (S) SS

SP: Parker Messick (LHP)

Notes

Houston looks to secure the series in Cleveland after taking the opener, with the focus shifting to whether the Astros can carry over yesterday’s momentum against a Guardians club that will be looking to even things up at Progressive Field. The Astros handled business in Game 1 and now have a chance to put immediate pressure on the Guardians, who will be looking to respond and even the series. With momentum on their side, Houston has an opportunity to keep things rolling before the series finale.